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EVALUATION OF RENAL FUNCTION IN NEONATAL RATS
Citation:
Kavlock, R. AND J. Gray. EVALUATION OF RENAL FUNCTION IN NEONATAL RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/169 (NTIS PB83209700).
Description:
The ontogenetic profile of several parameters of neonatal renal development in the rat is presented. Nephrogenesis was observed to continue at a rapid pace between birth and 8 days of age and to be virtually complete by 11 days of age. The activity of alkaline phosphatase, a brush border enzyme, declined during this time period relative to organ growth as a whole. The ability to elaborate a concentrated urine when presented with a period of fluid deprivation was barely present at birth and increased dramatically with age. Finally, the diuresis response to an orally administered water load was detected on the second post-natal day, while the response to antidiuretic hormones was present to a slight degree on the first postnatal day.