You are here:
CHARACTERIZATION OF A DEVELOPMENTAL TOXICOLOGY DOSE-RESPONSE MODEL
Citation:
Faustman, E., D. Wellington, W. Smith, AND C. Kimmel. CHARACTERIZATION OF A DEVELOPMENTAL TOXICOLOGY DOSE-RESPONSE MODEL. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/366.
Description:
The Rai and Van Ryzin dose-response model (1) proposed for teratology experiments has been characterized for its appropriateness and applicability in modeling developmental toxicity data. odifications were made in the initial probability statements to reflect more accurately biological events underlying developmental toxicity. ata sets used for the evaluation were obtained from the National Toxicology Program and U.S. EPA laboratories. he studies included developmental evaluations of ethylene glycol, diethylhexyl phthalate, di- and tri-ethylene glycol dimethyl ethers, and nitrogen in rats, mice, or rabbits. raphic examination and statistical evaluation demonstrate that this model is sensitive to the data when compared to directly measured experimental outcomes. he model was used to extrapolate to low-dose effect levels, and comparisons were made between the values obtained and the no observed effect levels (NOELS) divided by an uncertainty factor. ur investigation suggests that the Rai and Van Ryzin model is sensitive to the developmental toxicity and points, prenatal deaths and malformations, and appears to model closely their relationship to dose.