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BIOLOGICAL ASSESSMENT OF CONTINUOUS EXPOSURE TO TRITIUM AND LEAD IN THE RAT
Citation:
Cahill, D., L.W. Reiter, J. Santolucito, G. Rehnberg, AND M. Ash. BIOLOGICAL ASSESSMENT OF CONTINUOUS EXPOSURE TO TRITIUM AND LEAD IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-76/063 (NTIS PB268118).
Description:
In an attempt to contribute information on the effects of simultaneous exposure to two potentially synergistic environmental pollutants the authors have chronically administered tritiated water (HTO) and lead (Pb) to rats. HTO and Pb were selected because they are ubiquitous in the environment; technological advances have significantly increased their environmental levels; both are transplacentally transferred and can affect intrauterine development. Further, exposure to radiation or Pb in utero can produce postnatal neurological and reproductive dysfunction. The chronic exposure levels employed were 0.01 - 1.0 micro Ci HTO/ml body water (3-300 millirads/day) and 5 and 50 ppm of Pb in drinking water. These are, respectively, 2-200 times MPCw for an individual in the general population and 100-1000 times the U.S. Drinking Water Standards.