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COMPARABILITY OF RAT AND HUMAN VISUAL EVOKED POTENTIALS
Citation:
Hudnell, H. AND W. Boyes. COMPARABILITY OF RAT AND HUMAN VISUAL EVOKED POTENTIALS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/057 (NTIS PB91191643).
Description:
A series of experiments was conducted to assess the comparability of physiological processes in rat and human visual systems. n the first set of experiments, transient visual evoked potentials (VEPs) were elicited by the onset of sine-wave gratings of various spatial frequencies. he spatial frequency - response profiles of the first positive and immediately succeeding negative components differed from one another, but were similar in the two species. n addition, amplitude of the negative, but not the positive, component was strongly attenuated in both species following stationary pattern adaptation. n the second set of experiments, steady-state VEPs were elicited by the onset and offset of the gratings. he spatial frequency profiles of the 1F (response amplitude at the frequency of stimulus onset-offset) and 2F response components differed from one another, but were similar in both species. he final set of experiments indicated that diazepam, a GABA agonist reduced amplitude of 2F, but not 1F, in both species.