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THERMOREGULATORY RESPONSES OF THE RABBIT TO CENTRAL NEURAL INJECTION OF SULFOLANE
Citation:
Mohler, F. AND C. Gordon. THERMOREGULATORY RESPONSES OF THE RABBIT TO CENTRAL NEURAL INJECTION OF SULFOLANE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/326 (NTIS PB90216037).
Description:
Systemic exposure of the rabbit to sulfolane results in hypothermia; however, the mechanism of this thermoregulatory effect is unknown. his study was designed to determine the thermoregulatory effects of sulfolane on the central nervous system (CNs) of the rabbit. ale rabbits were stereotaxically implanted with an injection cannula over the preoptic/anterior hypothalamic area (POAH) or into the lateral cerebral ventricle.POAH temperature (TPOAH), ear temperature (Te), and metabolic rate (MR) were recorded at an ambient temperature (Ta) of l5 degrees C. o changes were observed in any of the thermoregulatory indices follwing injections of saline or sulfolane in dosages of 100, 300, and 1000 ug directly into the P0AH. ntracerebroventricular (ICV) injection of saline also had no effect on thermoregulation. owever, ICV sulfolane in dosages of 300, 1000, and 3000 ug caused TPOAH to rise 0.23, 0.47, and 0.56 degrees C, respectively. his hyperthermia was significant at a dosage of 3000 ug. here was no change in Te or MR at these three dose levels. icroinjection of 10,000 ug sulfolane ICV caused a slight decrease in TPOAH or 30 min which was accompanied by an increase in Te. ollowing the slight decrease, TPOAH increased to +0.54 degrees C at 120 min after injection as Te returned to baseline values. ata suggest that the previously observed thermoregulatory effects of sulfolane following systemic exposure cannot be attributed to a direct action of the parent compound on the CNS.