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YOHIMBINE ATTENUATES THE DELAYED LETHALITY INDUCED IN MICE BY AMITRAZ, A FORMAMIDINE PESTICIDE
Citation:
Moser, V. AND R. MacPhail. YOHIMBINE ATTENUATES THE DELAYED LETHALITY INDUCED IN MICE BY AMITRAZ, A FORMAMIDINE PESTICIDE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-85/306 (NTIS PB86162310).
Description:
The authors have found that a single dose of amitraz, a formamidine pesticide, produces death in mice which begins about two days after dosing and continues for up to 5 more days. To further examine the phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for eight days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz.