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SENSORY EVOKED POTENTIALS: MEASURES OF NEUROTOXICITY
Citation:
Boyes, W. SENSORY EVOKED POTENTIALS: MEASURES OF NEUROTOXICITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-92/065 (NTIS PB92164805).
Description:
There is a need for tests of sensory function to be incorporated in laboratory and toxicity testing. t is clear that sensory dysfunction may frequently occur, but go undetected, in standard animal toxicological testing protocols. ensory evoked potential technology can be employed to address this need, can provide information regarding perceptual deficits arising from toxic insults, and can yield information regarding possible mechanisms of action. n addition, sensory evoked potential changes in laboratory animals can be predictive of sensory changes in humans. urther research is needed to better define the neural substrates of evoked potentials and their perceptual correlates so that the implications of evoked potential changes for the cellular targets, mechanisms of actions, and perceptual correlates of evoked potential changes can be better understood. ore extensive use of these tools in human and animal toxicology is needed to better understand the ability of this methodology to detect sensory changes, and to predict human toxicity from animal data.