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'NEANTHES ARENACEODENTATA' (POLYCHAETA: ANNELIDA), A PROPOSED CYTOGENETIC MODEL FOR MARINE GENETIC TOXICOLOGY
Citation:
Pesch, G. AND C. Pesch. 'NEANTHES ARENACEODENTATA' (POLYCHAETA: ANNELIDA), A PROPOSED CYTOGENETIC MODEL FOR MARINE GENETIC TOXICOLOGY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-80/233 (NTIS PB81184715).
Description:
Genetic toxicants are present in polluted marine environments and may represent a long-term threat to populations of marine organisms. This paper presents details of an in vivo application of sister chromatid exchange (SCE) analysis to a marine polychaete worm Neanthes arenaceodentata. This species exhibits a dose response to mitomycin C (MMC) at concentrations comparable to those eliciting responses in in vivo mammalian systems. A dose of 5 x 10 to the minus 7th power mol/L MMC increased the rate of SCE from a baseline frequency of 0.14/chromosome to 0.5/chromosome. The chromosomes of N. arenaceodentata may provide a useful model for identifying and studying the effects of genetic toxicants in marine environments.