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EFFECTS OF LOW DOSAGE OF STABLE STRONTIUM ON SERUM ENZYMES IN CHRONIC ALCOHOLICS
Citation:
Pivon, R., P. Koch, J. Nolan, S. Skoryna, J. Perras, AND J. Stara. EFFECTS OF LOW DOSAGE OF STABLE STRONTIUM ON SERUM ENZYMES IN CHRONIC ALCOHOLICS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/032 (NTIS PB89223911).
Description:
Systemic effects of low dosage of stable Sr2+ have not been investigated previously with respect to chronic ethanol abuse. e have previously demonstrated that Sr2+ may exert a protective effect against mitochondrial injury in rats. he baseline data for the present investigation was established by a study of 83 chronic alcoholics admitted to a half-way treatment center. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-703 mg of Sr2+ per day) for periods of 4-6 weeks, alternating with treatment-free (Placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. erum Sr2+ and Ca2+ levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr2+, serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr2+ on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr2+ exerts a protective effect on mitochondrial function during acute alcoholic episodes.
