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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DINITROTOLUENE
Citation:
EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DINITROTOLUENE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-91/122.
Description:
Carcinogenicity data for mixed dinitrotoluenes are inadequate. ince the technical grade mixture consists of approximately 75% 2,4-dinitrotoluene and 19.5% 2,6-dinitrotoluene, hazard assessment for the mixture can be based on experimentation with the 2,4-isomer. Dinitrotoluene (mixture) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcinogenicity from animal studies is "Sufficient," and the evidence from human studies is "No Data." he potency factor (F) for dinitrotoluene (mixture) is the same as the factor for 2,4dinitrotoluene, which is 3.82 (mg/kg/day)-1. herefore, dinitrotoluene (mixture) can be placed in potency group 2 according to the CAG's methodology for evaluating potential carcinogens(U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, dinitrotoluene (mixture) is assigned a "MEDIUM" hazard ranking for the purposes of RQ adjustment.