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DEPOSITION PATTERNS OF AEROSOLIZED DRUGS WITHIN HUMAN LUNGS: EFFECTS OF VENTILATORY PARAMETERS
Citation:
Martonen, T. AND I. Katz. DEPOSITION PATTERNS OF AEROSOLIZED DRUGS WITHIN HUMAN LUNGS: EFFECTS OF VENTILATORY PARAMETERS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/031 (NTIS PB94137239).
Description:
An analytical model is used to study the effects of ventilatory parameters on particle deposition patterns within the human lung. ased upon fluid dynamics considerations (Reynolds numbers), an original method of partitioning the lung is presented. he model is validated by comparisons of predicted values with experimental data from adult subject inhalation exposure tests. y altering breathing profiles, deposition values can be affected egarding quantity delivered and spatial location. ncreased tidal volumes and breath-holding times increase deposition in the pulmonary region, while increased inspiratory flow rates increase deposition in the tracheobronchial region. he findings have implications with regard to aerosol therapy, indicating that the efficacies of inhaled pharmacological drugs in the prophylaxis and treatment of airway diseases can be improved by regulating breathing profiles to selectively deposit particles at prescribed sites within the lung.