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MYELIN BASIC PROTEIN-MESSENGER RNA (MBP-MRNA) EXPRESSION DURING TRIETHYLTIN-INDUCED MYELIN EDEMA
Citation:
Veronesi, B., K. Jones, S. Gupta, J. Pringle, AND C. Mezei. MYELIN BASIC PROTEIN-MESSENGER RNA (MBP-MRNA) EXPRESSION DURING TRIETHYLTIN-INDUCED MYELIN EDEMA. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/072 (NTIS PB92150861).
Description:
Triethyltin (TET) is a neurotoxicant that produces severe but transient cerebral edema, characterized ultrastructurally by vacuolation of the intraperiod line of central nervous system (CNS) myelin. ET has been reported to depress levels of myelin basic protein (MBP), a glycoprotein thought to play a critical role in myelin compaction. n the present study, the genomic expression (i.e. mRNA) of MBP was monitored throughout the pat-genesis of TET-induced myelin edema and recovery in Sprague-Dawley rats given a single injection of a neuropathic (8.0 mg/kg) or non-neuropathic (0.8 mg/kg) dose of TET-bromide. evels of MBP-mRNA from the anterior and posterior brain were derived 1 hr, 3 hr, 2d, and 7d, postexposure. ur data indicate that although all values were marked by high intragroup variability, TET stimulated MBP ranscript throughout the brain at all exposure time-points. he magnitude and time-course of this stimulation differed in the anterior and posterior brain with the posterior brain showing higher levels of MBP-mRNA brain, at both neuropathic and non-neuropathic doses. ltrastructural changes in the oligodendroglia suggestive of metabolic stimulation, correlated with of high MBP-mRNA levels. n summary, these data indicate that an initial genomic event in TET-induced myelin edemia is to stimulate synthesis of the targeted moiety (i.e., MBP). his study also suggests that differential sensitivity to TET-edema and genomic response exists anatomically.