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EPA'S REASSESSMENT OF DIOXIN RISK: DIRECTED HEALTH RESEARCH
Citation:
Birnbaum, L. EPA'S REASSESSMENT OF DIOXIN RISK: DIRECTED HEALTH RESEARCH. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/366 (NTIS PB93228922).
Description:
The United States Environmental Protection Agency initiated a reassessment of the risk of exposure to dioxin in the spring of 1991 because of the evolution of scientific thinking as well as the publication of several key experimental studies. his involves a literature reevaluation as well as laboratory studies in both health and ecological risks. ne of the major goals is development of a biologically based dose response model. irected health research involves comparison of sensitive responses in rats and mice, following both acute and chronic exposure, such as enzyme induction in multiple tissues, phosphorylation responses, tissue dosimetry, and effects on the immune system. he relative potency of 16 dioxin-like chemicals is being compared following chronic exposure in mice for a number of responses in several tissues to better estimate TEFs following low-level, repeated exposures. n addition, the levels of mRNA for induced enzymes is being correlated with the total TEQ in human livers from the general population.