Science Inventory

The Zebrafish (Danio rerio) Model in Toxicity Testing (Chapter 37)

Citation:

Padilla, S. AND S. Glaberman. The Zebrafish (Danio rerio) Model in Toxicity Testing (Chapter 37). Edition 1st, Chapter 37, Carey N. Pope and Jing Lui (ed.), An Intorduction to Interdisciplinary Toxicology: From Molecules to Man. Elsevier Inc, Waltham, MA, , 525-532, (2020). https://doi.org/10.1016/B978-0-12-813602-7.00037-5

Impact/Purpose:

An Introduction to Interdisciplinary Toxicology: From Molecules to Man 1st Edition, Chapter 37 Chapter 37 – The Zebrafish (Danio rerio) Model in Toxicity TestingThis is a review of the uses of zebrafish testing to inform both human health and ecological toxicity assessments.

Description:

The use of zebrafish in both human and ecological toxicity assessments is becoming more accepted as toxicologists begin the recognize what biologists have noted for the last decade: that there are many parallels between zebrafish and other vertebrate organisms, such that zebrafish are now another useful tool for human and ecological toxicity determinations. Zebrafish have become a popular model for both human and ecological toxicity assessments. This chapter discusses the scientific reasons for that popularity; describing many examples of similarities between zebrafish and mammalian function and development; how zebrafish have been used to discover novel pathways or mechanisms of toxicity; and the use of zebrafish as a model for ecological risk assessment, especially for rapid hazard testing and as bridge between laboratory and field-based studies. As toxicologists and regulators begin to recognize that there are many parallels between zebrafish and other vertebrate organisms, the use of zebrafish in both human and ecological toxicity assessments will become more common.