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Development of the Public-Facing ChemExpo Knowledgebase Web Application to Support Delivery of Chemical Use and Consumer Product Data (NC Symposium)
Citation:
Handa, S., K. Baron-Furuyama, K. Phillips, T. Wall, B. Horton, C. Lutz, A. Larger, K. Isaacs, AND C. Elonen. Development of the Public-Facing ChemExpo Knowledgebase Web Application to Support Delivery of Chemical Use and Consumer Product Data (NC Symposium). NC Symposium on Life/Data Sciences, Precision Medicine/Environmental Health, RTP, NC, May 08, 2023. https://doi.org/10.23645/epacomptox.22552882
Impact/Purpose:
ChemExpoDB is an integrated family of exposure databases, linking data across multiple different exposure data streams. The software application Factotum was developed to assist with managing, curating, and ensuring the quality of the data within ChemExpoDB. Factotum has facilitated the rapid collection and curation of chemical use data to improve the volume, quality and accessibility of exposure related data for decision making by EPA Stakeholders. To date, Factotum has been used to upload more than 560,000 publicly available data documents, with 4.0 million chemical-specific records extracted from these documents. Presently, 2.7 million of these raw chemical records have been curated to harmonized substance identifiers (DTXSIDs). Factotum will support a new public-facing data search and visualization tool, ChemExpo Explorer, that will display detailed curated data, including additional document metadata and raw reported information. This application will allow for interactive exploration of curated Factotum data by chemical, function, and consumer product category.
Description:
The US EPA is responsible for evaluating thousands of chemicals for the potential risks to humans and ecosystems, which necessitates information on hazard and exposure potential for each chemical. To support chemical decision-making, EPA's Office of Research and Development (ORD) must identify and characterize relevant exposure pathways - the path of a chemical from source to a receptor. How a chemical is used (e.g. in a consumer, occupational, or industrial context) is critical to determining exposure pathways. The ORD data management and curation application, Factotum, facilitates the rapid collection and distribution of high-quality chemical and exposure related data from public documents to inform chemical exposure and risk assessments. To date, Factotum has been used to collect and curate data from over 560,000 documents, representing 4 million individual chemical records and 35,000 unique chemical substances. A new publicly available data search and visualization tool, called Chemical Exposure Knowledgebase (ChemExpo), is being developed by ORD. ChemExpo will surface data managed and curated by the internal Factotum application. The initial release of ChemExpo will focus on specific chemical substances, chemical composition of consumer products, functional role of chemicals within products and processes, and presence of chemicals on reported specific or general use lists. This new application will display more detailed curated data than currently available on the EPA CompTox Chemicals Dashboard, including additional document metadata; product-level chemical ingredient information; and product category, function category, and chemical summaries. This application will allow for data exploration by chemical, function, and consumer product category to support exposure assessments and other risk-based chemical evaluations.
URLs/Downloads:
DOI: Development of the Public-Facing ChemExpo Knowledgebase Web Application to Support Delivery of Chemical Use and Consumer Product Data (NC Symposium)
POSTER.PDF (PDF, NA pp, 1492.177 KB, about PDF)