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ACUTE ELEVATION OF BLOOD CARBOXYHEMOGLOBIN TO 6% IMPAIRS EXERCISE PERFORMANCE AND AGGRAVATES SYMPTOMS IN PATIENTS WITH ISCHEMIC HEART DISEASE (JOURNAL VERSION)
Citation:
Adams, K., G. Koch, B. Chatterjee, G. Goldstein, AND J. O'Neil. ACUTE ELEVATION OF BLOOD CARBOXYHEMOGLOBIN TO 6% IMPAIRS EXERCISE PERFORMANCE AND AGGRAVATES SYMPTOMS IN PATIENTS WITH ISCHEMIC HEART DISEASE (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/267.
Description:
Acute exposure to carbon monoxide has the potential to impair exercise capacity in patients with ischemic heart disease. We studied the effect of inhalation of this compound sufficient to gradually produce a level of 6% carboxyhemoglobin in 30 non-smoking patients with obstructive coronary artery disease and evidence of exercise induced ischemia. On the carbon monoxide day, mean post exposure carboxyhemoglobin was 5.9 + or - 1% compared to 1.6 + or - 0.1% (p is less than .01) after air exposure. The results demonstrate earlier onset of ventricular dysfunction, angina, and poorer exercise performance in patients with ischemic heart disease after acute carbon monoxide exposure sufficient to increase carboxyhemoglobin to 6%. (Copyright (c) 1988 By the American College of Cardiology.)