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COMPARISON OF DNA ADDUCT LEVELS IN HUMAN PLACENTA FROM POLYCHLORINATED BIPHENYL EXPOSED WOMEN AND SMOKERS IN WHICH CYP 1A1 LEVELS ARE SIMILARLY ELEVATED
Citation:
Gallagher, J., R. Everson, J. Lewtas, M. George, AND G. Lucier. COMPARISON OF DNA ADDUCT LEVELS IN HUMAN PLACENTA FROM POLYCHLORINATED BIPHENYL EXPOSED WOMEN AND SMOKERS IN WHICH CYP 1A1 LEVELS ARE SIMILARLY ELEVATED. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/520 (NTIS PB95148821).
Description:
Cigarette smoking is associated with high elevations in levels of both cytochrome P450 1A1 (CYP 1A1) and DNA adducts in human placenta. he identity of the smoking related adducts is not known. he DNA adducts identified in placenta of smokers could result from chemicals resent in cigarette smoke, substances formed by CYP 1A1 metabolic activation of endogenous compounds, non-cigarette related exposures, or a combination of these processes. xposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFS) also resulted in massive elevation of CYP 1A1 in human placenta but formation of DNA adducts from this exposure has not previously been reported. sing 32p-potlabeling techniques that readily detect DNA adducts in placental tissue from smokers, we found no evidence of DNA adducts among specimens obtained from PCB/PCDF exposed individuals. hese data suggest that CYP 1A1 induction does not induce DNA adducts detectable by this approach, and that smoking related adducts are not a consequence of CYP 1A1 induction mediated activation of endogenous compounds or xenobiotics other than cigarette smoke