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SHORT-TERM SCREENING TEST FOR QUICK RESPONSES TO POLLUTANTS WHERE HEALTH EFFECTS DATA ARE LACKING
Citation:
Drummond, J., J. Fenters, R. Ehrlich, C. Aranyi, AND L. Schiff. SHORT-TERM SCREENING TEST FOR QUICK RESPONSES TO POLLUTANTS WHERE HEALTH EFFECTS DATA ARE LACKING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-82/004.
Description:
Results of assessment of various health effects parameters were correlated to determine which tests were the most sensitive indicators of toxic effects of exposure to sulfate aerosols. Inhalation studies were conducted involving single 3-hr exposure to various concentrations of cupric sulfate (0.43 - 2.64 mg/cu m), aluminum sulfate (1.65 - 2.75 mg/cu m), and aluminum ammonium sulfate (1.47 - 3.81 mg/cu m); and multiple 5 or 10 daily 3-hr exposures to cupric sulfate (0.1 mg/cu m). The test parameters studied in CD1 mice were changes in mortality after respiratory infection with Streptococcus pyogenes; pulmonary bactericidal activity; pulmonary cell number, type, viability, and ATP content; and pulmonary morphology by scanning electron microscopy. Trachael ciliary beating frequency and morphology were also studied in both CD1 mice and Syrian golden hamsters.