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ACRYLAMIDE: A REVIEW OF ITS GENOTOXICITY AND AN ASSESSMENT OF HERITABLE GENETIC RISK
Citation:
Dearfield, K.L., G. Douglas, U. Ehling, M. Moore, G. Sefa, AND D. Brusick. ACRYLAMIDE: A REVIEW OF ITS GENOTOXICITY AND AN ASSESSMENT OF HERITABLE GENETIC RISK. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/482.
Description:
This acrylamide assessment is the culmination of an effort emanating from an October 1993 joint European Commission/United tates EPA Workshop Risk Assessment examining "Human Genetic Risks from Exposure to Chemicals, Focusing on the Feasibility of a Parallelogram Approach". orkgroups were formed to review the genetic toxicity data for acrylamide, ethylene oxide, 1,3-butadiene, and cyclophosphamide. sing the available data and exposure information, the feasibility of conducting genetic risk assessment for adverse heritable effects was examined for the four compounds. he work of the acrylamide group is contained in this report. crylamide is an important industrial compound with many uses; for instance, polyacrylamides are used as flocculents for wastewater treatment, adhesives and grouts and in laboratory gels. hus, there are many opportunities for individuals to be exposed to monomeric acrylamide either in its production or its use. ecause of the known human exposure and the genetic effects induced by acrylamide in animals, it is important to examine the potential for inducing adverse heritable effects in exposed human beings. he present analysis builds upon preceding group efforts as well as the individual efforts referenced in this report. The International Commission for Protection Against Environmental Mutagens and Carcinogens (ICPEMC) has produced two reports: ne for the Department of Health, Canada and the other for the U.S. EPA. hese reports develop genetic risk extrapolation models. and the former report uses acrylamide data in presenting practical examples of risk estimation calculations. etailed description of the ECPEMC genetic risk extrapolation will be published elsewhere. he present workgroup expanded upon the ICPEMC calculation for acrylamide using different exposure scenarios for its genetic risk assessment.