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BEHAVIORAL TOXICITY OF TRIHALOMETHANE CONTAMINANTS OF DRINKING WATER IN MICE
Citation:
Balster, R. AND J. Borzelleca. BEHAVIORAL TOXICITY OF TRIHALOMETHANE CONTAMINANTS OF DRINKING WATER IN MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/370.
Description:
The behavioral toxicity of trichloromethane (TCM), dichlorobromomethane (DCBM), dibromochloromethane (DBCM) and tribromonethane (TBM) was evaluated following oral administration in mice. A variety of dosage regimens and behavioral measures were used. Studies included acute dose effect, 14- and 90-day treatments at 300 and 3000 times the estimated average human daily intake of contaminated drinking water, 30 days of 100 mg/kg/day, and 60 days of 100 and 400 mg/kg/day. In addition, TCM was tested for the production of taste aversions with 10-day administration and for behavioral teratology in offspring following extensive perinatal exposure.