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ROLE OF SURFACE COMPLEXED IRON IN OXIDANT GENERATION AND LUNG INFLAMMATION INDUCED BY SILICATES
Citation:
Ghio, A., T. Kennedy, A. Whorton, A. Crumbliss, G. Hatch, AND J. Hoidal. ROLE OF SURFACE COMPLEXED IRON IN OXIDANT GENERATION AND LUNG INFLAMMATION INDUCED BY SILICATES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/025 (NTIS PB93156297).
Description:
The hypothesis was tested that silica and silicate dusts complex iron on their surface and that this iron increases 1) in vitro oxidant generation, and mediator release by alveolar macrophages, and 2) acute inflammatory lung injury. ilica and silicates were found to complex more than ten times the Fe3+ onto their surfaces than did a biologically inactive dust, TiO2. ilica similarly demonstrated a greater capacity than control dust to complex iron from body sources after intratracheal injection in rats. he role of complexed iron in macrophage oxidant generation, mediator release, and acute inflammatory lung injury was investigated using iron loaded and unloaded silicates and using an iron chelator, deferoxamine. n vivo generation of oxidants by alveolar macrophages was measured after exposure to dusts was increased by surface complexed iron. lso, acute inflammatory lung injury after intratracheal injection of silica dusts was made more severe by surface iron. e conclude that silica and silicate surfaces complex Fe3+ to increase oxidant generation, and mediator release by alveolar macrophages, and to increase acute lung injury in the rat.
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ROLE OF SURFACE COMPLEXED IRON IN OXIDANT GENERATION AND LUNG INFLAMMATION INDUCED BY SILICATES