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SYNAPTONEMAL COMPLEX ABERRATIONS IN THE PSEUDOAUTOSOMAL REGION OF X,Y CHROMOSOMES IN IRRADIATED HAMSTERS
Citation:
Allen, J.W., P. Poorman-Allen, B. W, Collins, AND M. Sontag. SYNAPTONEMAL COMPLEX ABERRATIONS IN THE PSEUDOAUTOSOMAL REGION OF X,Y CHROMOSOMES IN IRRADIATED HAMSTERS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/133.
Description:
Armenian hamsters were treated with X-radiation, bleomycin or amsacrine (m-AMSA) and the effects on meiotic chromosomes determined by electron microscopic analysis of synaptonemal complex (SC) formation. achytene cells were analyzed five or six days following their treatment at putative preleptotene-leptotene stages of meiosis. of the multiple types of SC aberrations observed to be significantly increased over control levels, lateral element breakage and synaptic anomalies were most prevalent. he focus of these studies was on the sex chromosomes which, in the Armenian hamster, reveal an unusually well-defined pseudoautosomal region. n the XY pair, radiation and chemical treatments caused certain forms of structural and synaptic anomalies which appeared to be preferentially localized to telomeric and/or crossover regions. he nature of these specific aberrations, involving breakage, bridge formation and asynapsis, is not well understood; however, their distributions are suggestive of possible relationships with sites/processes of crossing over.