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EFFECTS OF LOW LEVEL CARBON MONOXIDE EXPOSURE. BLOOD LIPIDS AND COAGULATION PARAMETERS
Citation:
Brinkhouse, K. EFFECTS OF LOW LEVEL CARBON MONOXIDE EXPOSURE. BLOOD LIPIDS AND COAGULATION PARAMETERS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/032.
Description:
The study examined the effects of carbon monoxide (CO) in 50 and 100 ppm doses on response to treadmill exercise, blood coagulation and blood lipids in normal men. Twenty-three men were exposed to CO or to air in a double-blind protocol. After exposure, each underwent a graded exercise treadmill test which was terminated at 85% maximal heart rate. Blood for measurement of carboxyhemoglobin (COHb), hematocrit, platelet count, prothrombin time, partial thromboplastin time, thrombin time, fibrin split products, factor VIII, platelet aggregation, serum cholesterol and triglycerides was drawn at baseline, preexercise and postexercise. COHb did not change on air days but reached a mean of 2.17% on 50 ppm days and 4.15% on 100 ppm days. The mean duration of exercise was 19 sec shorter on CO days than on air days (f = 4.93). The greatest effect was on 100 ppm days (f = 8.00). Coagulation parameters and cholesterol and triglyceride measurements were not significantly affected by CO exposure.