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RETINOIDAL BENZOIC ACIDS (AROTENOIDS) AND OTHER RETINOIDS INHIBIT IN VITRO TRANSFORMATION OF EPITHELIAL CELLS
Citation:
Mass, M. RETINOIDAL BENZOIC ACIDS (AROTENOIDS) AND OTHER RETINOIDS INHIBIT IN VITRO TRANSFORMATION OF EPITHELIAL CELLS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/077 (NTIS PB90245499).
Description:
Five retinoids were calcluated for their ability to inhibit N-methyl-N'nitro-N-nitrosoguanidine (MNNG)-induccd transformation of primary rat trachcal epithelial (RTE) cells in culture at concentrations that did not affect cell survival. wo retinoidal benzoic acids (arotcnoids), Ro 13-6298 and Ro 13-7410, suppressed the transformation frequency by 8O-9O% at 330 pM whereas at 330 pM retinoic acid suppressed the transformation frequency by 50%. n addition, retinol and retinyl acetate were tested at 33 nM and found to be much less effective than RA at this concentration. n studies with all retinoids, the spontaneously occurring transformed epithelial foci were suppressed from arising by a greater extent than were those that arose in response to carcinogen treatment. iological difference between carcinogen-induced and spontaneously arising foci is suggested by this result.