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PREDICTION OF CARBOXYHEMOGLOBIN FORMATION DUE TO TRANSIENT EXPOSURE TO CARBON MONOXIDE
Citation:
Benignus, V., M. Hazucha, M. Smith, AND P.A. Bromberg. PREDICTION OF CARBOXYHEMOGLOBIN FORMATION DUE TO TRANSIENT EXPOSURE TO CARBON MONOXIDE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/517 (NTIS PB95148797).
Description:
Prediction of carboxyhemoglobin formation due to transient xposure to carbon monoxide. . Appl. Physiol. 76(4):1739-1745, 1994.-Fifteen men were exposed to 6,683 ppm C18O for 3.09-6.65 min. rterial and antecubital vein blood samples were drawn at 1-min intervals beginning at the start of C18O inhalation and ending 10 min later. imultaneously, alveolar ventilation was calculated from the measured values of minute ventilation and dead space. ll other parameters of the Coburn-Forster-Kane equation (CFKE), except the Haldane affinity ratio, were measured separately in each subject. eans of CFKE predictions of increases in venous HBCO (AHBCO) in samples collected -2 min after cessation of exposure were accurate, but the range in errors of prediction for individual subjects was +/-3.8% HBCO, depending on the time after exposure cessation. ncreases in venous and arterial HBCO were inaccurately predicted during and immediately after HBCO formation, however. enous blood was overestimated during CO uptake because of a delayed appearance of HBCO. ndividual subjects differed markedly in the degree of delay of HBCO appearance in venous blood. rterial AHbCO was consistently underestimated either by the CFKE or by predictions based on venous blood samples. hus, exposure of such organs as brain or heart to HBCO may be substantially higher than expected during transient high-level CO exposure.