Citation:

Chuang, J., S. Wise, S. Cao, AND J. Mumford. CHEMICAL CHARACTERIZATION OF MUTAGENIC FRACTIONS OF PARTICLES FORM INDOOR COAL COMBUSTION: A STUDY OF LUNG CANCER IN XUAN WEI, CHINA. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/379 (NTIS PB93231835).

Description:

In the rural Xuan Wei County, Yunnan Province, women's lung cancer mortality rates are among the highest in China. ost of these women are nonsmokers and studies have shown that lung cancer in Xuan Wei is associated with domestic use of smoky coal under unvented conditions. o investigate the etiology of lung cancer in Xuan Wei, China, a composite sample of organic extract of fine indoor particles (<10 um) collected from one home using smoky coal for cooking was characterized by using bioassay-directed high performance liquid chromatography (HPLC) fractionation and chemical characterization of the mutagenic components. he high-volume filter samples collected from the home inhabited by a person with lung cancer during cooking periods on four consecutive days were subjected to Soxhlet extraction. his composite sample extract was fractionated on a normal-phase HPLC column into seven fractions. he second fraction was the most active, containing mainly polycyclic aromatic hydrocarbon (PAH) and alkylated PAH. he two polar fractions 6 and 7 were the next most active. he most active PAH fraction was further divided into 11 subfractions, based on the number of aromatic carbons in PAH. he results indicated that the presence of 3- to 4-ring alkylated PAH in the sample extract is a significant factor that may be linked to the high incidence of lung cancer in Xuan Wei, China.

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