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TOXICITY OF MERCURIC CHLORIDE TO THE DEVELOPING RAT KIDNEY. 3. DISTRIBUTION AND ELIMINATION OF MERCURY DURING POSTNATAL MATURATION
Citation:
Daston, G., B. Rehnberg, L. Hall, AND R. Kavlock. TOXICITY OF MERCURIC CHLORIDE TO THE DEVELOPING RAT KIDNEY. 3. DISTRIBUTION AND ELIMINATION OF MERCURY DURING POSTNATAL MATURATION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/480 (NTIS PB89105456).
Description:
Mercuric chloride is a potent nephrotoxin in the adult rat, but has little effect on newborns. Nephrotoxicity increases with postnatal maturation. The study assesses the changes in tissue distribution and excretion of Hg during postnatal development. Sprague Dawley rats were injected so with 5 mg/kg (203)HgCl2 on postnatal day 1, 8, 15, 22 or 29. Hg concentration was measured in the whole body, renal cortex, medulla and papilla, liver, and subcellular fractions of liver and kidney. Binding to cytosolic metallothionein was assessed.