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TERATOGENESIS, TOXICITY, AND BIOCONCENTRATION IN FROGS EXPOSED TO DIELDRIN
Citation:
Schuytema, G., A. Nebeker, W. Griffis, AND K. Wilson. TERATOGENESIS, TOXICITY, AND BIOCONCENTRATION IN FROGS EXPOSED TO DIELDRIN. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/171 (NTIS PB92180363).
Description:
Teratogenesis, acute and chronic toxicity, and bioconcentration were investigated in various like stages of African clawed frogs (Xenopus laevis), bullfrogs (Rana catesbeiana) and leopard frogs (Rana pipiens) exposed to aqueous dieldrin in static-renewal and continuous-flow tests. adpole 96-hr LC50s ranged from 40.4 to 49.5 ug/L for Xenopus, from 8.7 to 30.3 ug/L for bullfrogs and was 71.3 ug/L for leopard frogs. he 24-day LC50 for Xenopus tadpoles was 5.5 ug/L; the 28-day LC50 for leopard frog tadpoles was 8.3 ug/L. dult leopard frogs had a 28-day LC50 of 53.4 ug/L. erata in Xenopus embryo-larval tests occurred at concentrations as low 1.3 ug/L after 10 days. ean steady-state bioconcentration factors (BCF) for tadpoles ranged from 430 for Xenopus and from 540 to 1,130 for leopard frogs. ean steady-state BCFs for adult leopard frog skin, muscle and liver ranged from 40 to 310. xisting dieldrin water quality criteria values appear to protect frogs. he relative similarity of response of the frogs to dieldrin emonstrates the usefulness of Xenopus in assessing potential environmental hazards.