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TOXICOLOGY OF COMPLEX MIXTURES OF INDOOR AIR
Citation:
Lewtas, J. TOXICOLOGY OF COMPLEX MIXTURES OF INDOOR AIR. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/243 (NTIS PB90129289).
Description:
This review focuses on strategies for assessing the toxicology of indoor air pollutant mixtures. hese strategies are illustrated by reviewing the current problems and approaches to the toxicology of indoor air pollutants from three indoor source categories which make a major contribution to human exposure: environmental tobacco smoke, combustion emissions, and volatile organic compound (VOC) mixtures from materials and products. he strategies include assessment of: exposure and dosimetry, toxic effects of mixtures, causative agents in mixtures, and the predictability of toxicology from one mixture to another. ase studies from indoor air pollution are used to illustrate these strategies. nvironmental tobacco smoke research on exposure and dosimetry illustrates new methods using biological markers. nvented combustion sources such as kerosene heaters emit genotoxic incomplete combustion products and recent research is focused on identifying the genotoxic (causative) agents in these mixtures. OC mixtures emitted from materials and products are thought to pose potential health hazards and new approaches to identifying specific toxic effects in humans and animals exposed to such mixtures are discussed.