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Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
Citation:
Viant, M., T. Ebbels, R. Beger, D. Epps, H. Kamp, P. Leonards, G. Loizou, J. MacRae, B. van Ravenzwaay, P. Rocca-Serra, R. Salek, T. Walk, R. Weber, AND D. Ekman. Use cases, best practice and reporting standards for metabolomics in regulatory toxicology. Nature Communications. Nature Publishing Group, London, Uk, 10:3041, (2019). https://doi.org/10.1038/s41467-019-10900-y
Impact/Purpose:
This publication aims to describe the most relevant best practice guidelines, method performance standards, and minimal reporting standards for the acquisition, processing and statistical analysis of metabolomics data within the context of regulatory toxicology. This document has been developed as part of the MEtabolomics standaRds Initiative in Toxicology (MERIT) project. Specifically, we aim to provide regulators and other stakeholders with the first practical guidelines for interpreting the quality of metabolomics data. To facilitate this, we have considered the most immediate potential applications for metabolomics in regulatory toxicology and used these as a foundation for the development of the standards. We recognise that technologies evolve, as do regulatory needs, hence we regard this publication as a living document that will require version-controlled refinements in the future. Furthermore, the document provides a basis for the development of an international OECD guidance document and reporting template: the OECD Metabolomics Reporting Framework (MRF), initiated in 2018.
Description:
Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.
URLs/Downloads:
DOI: Use cases, best practice and reporting standards for metabolomics in regulatory toxicology