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A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways
Citation:
Price, P. AND J. Leonard. A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 16:58-99, (2019). https://doi.org/10.1016/j.cotox.2019.05.007
Impact/Purpose:
Assessing risks from chemicals requires an understanding of how concurrent exposures to multiple chemicals can affect an individual's risks. While interactions between the toxicity of chemicals has been studied for more than 100 years there is no single system for organizing data on chemical interactions. This paper proposed such a system. The system includes interactions that occur aver the entire source-to-exposure-response continuum. The system may assist in the design of databases, information pipelines, and models of responsechemical interactions that will support high throughput assessments of cumulative risk.
Description:
Currently, there is no single taxonomy for organizing data on the various types of chemical interactions that may affect risks from combined exposures. A taxonomy of chemical interactions is proposed that is based on a combination of the aggregate exposure pathways (AEPs) and adverse outcome pathways (AOPs) (AEP–AOP framework). The AEP–AOP framework organizes data on the causal events that ocur over the entire source–exposure–response continuum of a chemical's release. The proposed taxonomy uses this framework in two ways. First, four top-level categories are established based on the location in the continuum where a chemical interaction occurs. Second, each top-level category has two or more subcategories that are based on concepts taken from AEPs and AOPs. The categories and subcategories are potentially useful in developing standardized definitions for interaction terms and improving our understanding of the impacts of chemical interactions on risk to human health and the environment.
URLs/Downloads:
DOI: A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways