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EFFECTS OF POSTNATAL TRIMETHYLTIN OR TRIETHYLTIN TREATMENT OF CNS CATECHOLAMINE, GABA (GAMMA-AMINOBUTYRIC ACID), AND ACETYLCHOLINE SYSTEMS IN THE RAT
Citation:
Mailman, R., M. Krigman, G. Frye, AND I. Hanin. EFFECTS OF POSTNATAL TRIMETHYLTIN OR TRIETHYLTIN TREATMENT OF CNS CATECHOLAMINE, GABA (GAMMA-AMINOBUTYRIC ACID), AND ACETYLCHOLINE SYSTEMS IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/310.
Description:
The effects on brain neurochemistry of two neurotoxic tin compounds, trimethyltin (TMT) hydroxide and triethyltin (TET) sulfate, were examined. Long-Evans rats were treated with TMT hydroxide (1 mg/kg, i.p.) on alternate days from day 2 to 29 of life. These treatments caused a weight deficit of 10-20% by the time the animals were killed on day 55 by head-focused microwave irradiation. These TMT treatments are known to cause severe neuronal loss in the hippocampus and lesser damage in other brain regions. (Copyright (c) 1983 International Society for Neurochemistry.)