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DISTRIBUTION OF 2,4,5-TRICHLOROPHENOXYACETIC ACID IN THE MOUSE FETUS
Citation:
Courtney, K., M. Brown, AND A. Tucker. DISTRIBUTION OF 2,4,5-TRICHLOROPHENOXYACETIC ACID IN THE MOUSE FETUS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-77/125 (NTIS PB284757).
Description:
The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) readily crosses the placenta in the mouse on gestational day 13. Concentrations of 2,4,5-T in maternal tissues and fetuses were obvious at 30 min., highest at 8 h, diminished by 24 h and almost entirely eliminated by 48 h. Autoradiographs of the whole fetus showed that initially 2,4,5-T was mainly in the highly vascularized tissues such as liver followed by the skin, eyes and ventricles of the brain. At 48 h, there was a general distribution of 2,4,5-T in the skeletal muscles. None was detected in the palate. The excretion rate in the mouse was approximately 60 micrograms/h; about 52% of the dose was recovered unchanged in the urine in 24 h.