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ASSESSMENT OF CHEMICALLY-INDUCED ALTERATIONS IN BRAIN DEVELOPMENT USING ASSAYS OF NEURON- AND GLIA-LOCALIZED PROTEINS
Citation:
O'Callaghan, J. AND D. Miller. ASSESSMENT OF CHEMICALLY-INDUCED ALTERATIONS IN BRAIN DEVELOPMENT USING ASSAYS OF NEURON- AND GLIA-LOCALIZED PROTEINS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/438 (NTIS PB91109306).
Description:
Chemical intervention during prenatal or postnatal ontogeny can result in complex biochemical, morphological and behavioral alterations in brain development (Suzuki, 1980; Miller and O'Callaghan, 1984; Rodier, 1986; Ruppert, 1986). s has been shown at this conference (e.g. by Hammer and coworkers), the knowledge of specific actions of a given drug/chemical in the adult can serve as a guide for choosing processes affected by the same compound administered during development. ommonly, however, the neuronal or glia substrates for chemical action in the developing brain are not known and cannot be easily predicted ont he basis of the effects observed in the mature animal. ndeed, there are a multitude of structurally dissimilar compounds that affect diverse and unpredictable targets in the developing brain (Spencer and Schaumburg, 1980; Cranmer and Tilson, 1986). he focus of this review is to present an approach for detecting and characterizing chemically-altered brain development that can be used regardless of the information available on the chemical in question.