You are here:
AH RECEPTOR IN EMBRYONIC MOUSE PALATE AND EFFECTS OF TCDD ON RECEPTOR EXPRESSION
Citation:
Abbott, B., G. Perdew, AND L. Birnbaum. AH RECEPTOR IN EMBRYONIC MOUSE PALATE AND EFFECTS OF TCDD ON RECEPTOR EXPRESSION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/040.
Description:
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent and widespread environmental contaminant, has diverse biological effects which include carcinogenesis, hepatotoxicity, thymic involution, hyperkeratosis, reproductive and developmental toxicity. n C57BL/6N embryonic mouse, TCDD induces cleft palate through effects on differentiation and proliferation, which are mediated through binding to the Ah receptor. n this study, Ah receptor expression in palatal cells differed between epithelial and mesenchymal cells and TCDD-exposure downregulated both MRNA and protein. n the embryonic palate, the specific localization of Ah receptor within cells and across tissues raises questions about the extrapolation of results from cultured tumor cells to the in vivo situation.