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METHOD FOR COMPARING, COMBINING AND INTERPRETING SHORT-TERM GENOTOXICITY TEST DATA: THE BASIC SYSTEM
Citation:
Lohmar, P., M. Mendelsohn, D. Moore, M. Waters, D. Brusick, J. Ashby, AND W. Lohmar. METHOD FOR COMPARING, COMBINING AND INTERPRETING SHORT-TERM GENOTOXICITY TEST DATA: THE BASIC SYSTEM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/399 (NTIS PB93236362).
Description:
Short-term testing methods, encompassing a wide variety of species and genetic mechanisms, have been developed to detect genetic effects produced by chemicals. he use of a multiplicity of tests has created a difficult and controversial challenge in the interpretation of mixed test results. he driving principle of this report and ICPEMC Committee 1 was to combine the major parameters of testing (dose, metabolic activation, sign of response, and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation), and by family (in vitro or in vivo), into a composite score for a chemical. he system is designed (i) to cope with redundant data, disagreement, and sporadically filled matrices; (ii) to supply statistical properties by chemical and by test; and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard.