Science Inventory

Triaging Exposure Data and Modeling Needs for Exogenous Chemicals: Comparing High-Throughput and Traditional Exposure Estimates

Citation:

Isaacs, K. Triaging Exposure Data and Modeling Needs for Exogenous Chemicals: Comparing High-Throughput and Traditional Exposure Estimates. Acelerating the Pace of Chemical Risk Assessment, Ottawa, CANADA, October 10 - 11, 2018. https://doi.org/10.23645/epacomptox.7450964

Impact/Purpose:

This product describes a comparison between new high-throughput new approach methods (NAM) for exposure to traditional exposure assessments. These comparisons aid in the evaluation of these NAM for evaluation of chemicals in the regulatory context.

Description:

Kristin Isaacs will attend the Accelerating the Pace of Chemical Risk Assessment (APCRA) Workshop in Ottawa, Canada, October 9-11, 2018. This is the third annual workshop on new approach methods (NAMs) for generating safety information on chemicals. It is being convened with key international regulatory agencies and their science support colleagues to discuss progress in applying the new tools to prioritization, screening, and quantitative risk assessments (RAs) of differing levels of complexity. Scientific and regulatory needs for the quantitative application and acceptance of NAMs for RA continue to be identified, and example case studies designed to address them in a collaborative manner. The case studies being conducted by multinational groups will be presented and discussed. Kristin Isaacs will present the results of the case study (described here) comparing high-throughput exposure data with traditional exposure assessments. She led this case study in collaboration with Health Canada and the European Chemicals Agency exposure scientists. She will also be coordinating with international partners on the publication of this research.