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PROTEIN ADDUCT FORMING CHEMICALS FOR EXPOSURE MONITORING: CHEMICALS SELECTED FOR FURTHER STUDY
Citation:
Schnell, F. AND T. Chiang. PROTEIN ADDUCT FORMING CHEMICALS FOR EXPOSURE MONITORING: CHEMICALS SELECTED FOR FURTHER STUDY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/4-89/035.
Description:
The present report is an in-depth characterization of twenty-two chemicals and the protein (primarily hemoglobin) adducts that are formed following exposure to these compounds. These chemicals were recommended for further study in a recent internal report which described the state of the science with regard to chemicals and adducts potentially of interest for exposure monitoring. The topics covered for each individual chemical include manufacture and use, sources and levels of exposure, known health effects, metabolic detoxification and activation, host factors, adduct characterization, rates of adduct formation, dose-response relationships, background adduct levels, methods of adduct detection, and research needs. The twenty-two compounds which are evaluated are ranked and placed in one of the following categories: 1) Simple alkylating and arylating agents that form N-terminal valine adducts, 2) Aromatic amines that form hydrolyzable cysteine adducts, 3) Chemicals that form hydrolyzable, but less well-characterized adducts, 4) Chemicals that form characterized, but nonhydrolyzable adducts, and 5) Chemicals that form poorly chaacterized adducts.