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COMPARATIVE G.I. ENZYME ACTIVITY AND ACTIVATION OF THE PROMUTAGEN 2,6-DINITROTOLUENE IN MALE CD-1 MICE AND MALE FISCHER 344 RATS
Citation:
Chadwick, R., S. George, J. Chang, M. Kohan, J. Dekker, J. Long, AND M. Duffy. COMPARATIVE G.I. ENZYME ACTIVITY AND ACTIVATION OF THE PROMUTAGEN 2,6-DINITROTOLUENE IN MALE CD-1 MICE AND MALE FISCHER 344 RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/169 (NTIS PB91115816).
Description:
Comparative intestinal nitroreductase, azo reductase, B-glucuronidase, dechlorinase, and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-l mice were measured in vitro while the comparative biotransformation of 2,6 dinitrotoluene to mutagenic metabolites was determined vivo. he mice, which exhibit a high spontaneous incidence of hepatomas had markedly greater nitroreductase activity and metabolized significantly more 2,6 dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. esults of this study indIcate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract.