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DNA ADDUCT FORMATION BY 7,12-DIMETHYLBENZ(A)ANTHRACENE AND ITS NONCARCINOGENIC 2-FLUORO ANALOGUE IN FEMALE SPRAGUE-DAWLEY RATS
Citation:
Daniel, F. AND N. Joyce. DNA ADDUCT FORMATION BY 7,12-DIMETHYLBENZ(A)ANTHRACENE AND ITS NONCARCINOGENIC 2-FLUORO ANALOGUE IN FEMALE SPRAGUE-DAWLEY RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/008 (NTIS PB83194548).
Description:
The potent polycyclic aromatic hydrocarbon 7.2 dimethylbenz(a)anthracene (DMBA) bound to the DNA of numerous organs of the female outbred Sprague-Dawley rat after iv administration under a regimen known to produce a high yield of mammary adenocarcinomas. The maximum DNA binding levels observed following iv administration of 5 mg DMBA range from approximately 12 micromol hydrocarbon/mol deoxyribonucleic for the liver to approximately 5 micromol hydrocarbon/mol deoxyribonucleotide for the mammary gland, the target tissue.