EPA announced the availability of the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) for a 30-day public comment period. Information regarding the implementation of systematic review in the IRIS Program is described in a January 2018 Memo.

Citation:

U.S. EPA. Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/486, 2018.

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This document presents a draft assessment plan for chloroform that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in September 2017 and that will define the scope and approach of the IRIS assessment for chloroform.

Description:

In January 2018, EPA released the Systematic Review Protocol for the Chloroform IRIS Assessment (Inhalation). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

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