Citation:

Conley, J. Complex mixtures of anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat. CSS RAP, RTP, NC, August 14 - 15, 2017.

Impact/Purpose:

Humans are typically exposed to more than one chemical at a time and federal statutes direct USEPA to assess risk based on cumulative exposures to chemicals that act similarly. We tested the hypothesis that in utero exposure to mixtures of chemicals covering multiple “anti-androgenic” mechanisms of action at low doses would result in permanent reproductive tract alterations in the male rat. We grouped chemicals in the mixture based on an anti-androgen AOP network for chemicals that affect the fetal androgen signaling pathway. Male offspring displayed a variety of neonatal, pubertal, and permanent adult effects across a range of dose levels. Our results indicate that anti-androgenic chemicals act in a dose additive manner and in utero exposure produces permanent adverse effects at low individual chemical doses. It also contributes to a CSS AOPDD (17.1) deliverable.

Description:

This product is a powerpoint presentation for use in two invited talks (webinars) as part of the CSS RAP. There is no abstract to attach as this is not a conference presentation and an abstract was not required or prepared. The CSS NPD talk will be August 14 and the CSS AOPDD Webinar will be August 15.

Record Details: