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Triaging Chemical Exposure Data Needs and Tools for Advancing Next-Generation Risk Assessment
Citation:
Isaacs, K., J. Wambaugh, AND J. Orme-Zavaleta. Triaging Chemical Exposure Data Needs and Tools for Advancing Next-Generation Risk Assessment. Accelerating the Pace of Chemical Risk Assessment, Helsinki, FINLAND, October 10 - 11, 2017.
Impact/Purpose:
This effort evaluates the exposure landscape in the context of rapid risk assessment (RA) and chemical prioritization, with the goal of identifying the key data gaps contributing to the hindrance of efficient chemical assessments.
Description:
The timely assessment of the risks posed to public health by tens of thousands of existing and emerging commercial chemicals is a critical challenge facing the U.S. Environmental Protection Agency and regulatory bodies worldwide. The pace of conducting risk assessments is limited by the pace at which both credible and reliable information can be generated on anticipated biological effects and on expected exposure concentrations. This research is driven by the need to provide the exposure component of high-throughput risk metrics for the prioritization of thousands of chemicals in OCSPP regulatory programs, including the Endocrine Disruptor Screening Program (EDSP). Previous work by EPA (Egeghy et al. 2012) demonstrated that with the exception of pesticides, the exposure data landscape (e.g. chemical use data, monitoring data, pharmacokinetic data) for commercial chemicals was extremely limited. However, in the last several years under the ExpoCast program, EPA has been generating databases and predictive tools to improve our ability to characterize exposure. We now propose a formal effort to re-evaluate the exposure landscape in the context of risk assessment (RA), with the goal of identifying the key data gaps contributing to the hindrance of efficient chemical assessments.