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Inflammatory Cell signaling following Exposures to Particulate Matter and Ozone
Citation:
Yan, Z., Y. Jin, Z. An, Y. Liu, J. Samet, AND W. Wu. Inflammatory Cell signaling following Exposures to Particulate Matter and Ozone. Biochimica et Biophysica Acta. Elsevier Science Ltd, New York, NY, 1860(12):2826-34, (2016).
Impact/Purpose:
Particulate matter (PM) and ozone (03) are two major ambient air pollutants. Epidemiological and toxicological studies have demonstrated exposure to these pollutants is associated with a variety of adverse health effects, including cardiovascular and respiratory disease,in which inflammation is believed to be a common and essential factor.
Description:
This review mainly focuses on major inflammatory cell signaling pathways triggered byexposure to PM and 03. The receptors covered in this review include the EGF receptor, toll like receptor,and NOD-like receptor. Intracellular signaling protein kinases depicted in this review are phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Activation of antioxidant and inflammatory transcription faators such as NrF2 and NFKB induced by PM and 03 is also discussed.
