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Analysis of ToxCast data for food-relevant compounds by comparison with in vivo data using the RISK21 approach
Citation:
Turley, A., K. Isaacs, B. Wetmore, AND A. Karmaus. Analysis of ToxCast data for food-relevant compounds by comparison with in vivo data using the RISK21 approach. 10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20 - 24, 2017.
Impact/Purpose:
We present case studies comparing the ToxCast and in vivo toxicity data for two food contact substances using the RISK21 approach.
Description:
The ToxCast program has generated a wealth of in vitro high throughput screening data, and best approaches for the interpretation and use of these data remain undetermined. We present case studies comparing the ToxCast and in vivo toxicity data for two food contact substances using the RISK21 approach. Available exposure data, toxicity data, and model predictions were analyzed for sodium pyrithione and dibutyltin dichloride. In-vitro to in-vivo extrapolation (IVIVE) was performed to determine oral equivalent doses (OEDs) for the ToxCast data bioactivity. For sodium pyrithione, calculated OEDs corresponded to doses that demonstrated toxicity in animal studies. For dibutyltin dichloride, calculated OEDs were below the doses that demonstrated toxicity in animals, but this was confounded by the conservative estimates used in the IVIVE calculations. These studies highlight the potential of the ToxCast approach while also indicating areas where additional data or predictive tools are needed.
