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A Vignette (User’s Guide) for “An R Package for Statistical Analysis of Chemistry, Histopathology, and Reproduction Endpoints Including Repeated Measures and Multi-Generation Studies (StatCharrms).”
Citation:
Flynn, K. AND J. Swintek. A Vignette (User’s Guide) for “An R Package for Statistical Analysis of Chemistry, Histopathology, and Reproduction Endpoints Including Repeated Measures and Multi-Generation Studies (StatCharrms).”. U.S. EPA Office of Research and Development, Washington, DC, 2017.
Impact/Purpose:
This document provides a User’s Manual (termed a Vignette by the Comprehensive R Archive Network (CRAN)) for the previously created R-code tool called StatCharrms (Statistical analysis of Chemistry, Histopathology, and Reproduction endpoints using Repeated measures and Multi-generation Studies). The StatCharrms R-code has been publically available directly from EPA staff since the approval of OCSPP 890.2200 and 890.2300, and now is available publically available at the CRAN.
Description:
StatCharrms is a graphical user front-end for ease of use in analyzing data generated from OCSPP 890.2200, Medaka Extended One Generation Reproduction Test (MEOGRT) and OCSPP 890.2300, Larval Amphibian Gonad Development Assay (LAGDA). The analyses StatCharrms is capable of performing are: Rao-Scott adjusted Cochran-Armitage test for trend By Slices (RSCABS), a Standard Cochran-Armitage test for trend By Slices (SCABS), mixed effects Cox proportional model, Jonckheere-Terpstra step down trend test, Dunn test, one way ANOVA, weighted ANOVA, mixed effects ANOVA, repeated measures ANOVA, and Dunnett test.
