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Product Deformulation to Inform High-throughput Exposure Predictions (SOT)
Citation:
Wambaugh, J., A. Yau, K. Phillips, K. Favela, C. Nicolas, D. Biryol, Chris Grulke, A. Richard, Paul S Price, K. Isaacs, AND R. Thomas. Product Deformulation to Inform High-throughput Exposure Predictions (SOT). Presented at Society of Toxicology, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5176402
Impact/Purpose:
Present preliminary results of the ExpoCast data contracts to the Society of Toxicology annual meeting.
Description:
The health risks posed by the thousands of chemicals in our environment depends on both chemical hazard and exposure. However, relatively few chemicals have estimates of exposure intake, limiting the understanding of risks. We have previously developed a heuristics-based exposure estimation method that depends on simple factors such as the presence or absence of chemicals in consumer products to estimate exposure for thousands of chemicals. Although this method was predictive when compared with human biomonitoring data, limited data are available on the chemical constituents within most articles of commerce. We aim to broaden the number of products with constituent chemical information and refine exposure models by quantifying constituent concentration. A selection of five samples each from 20 diverse consumer product categories (e.g., lotion, clothing, carpet) were analyzed using solvent extraction followed by gas chromatograph (GC) x GC Time of Flight Mass Spectrometry (GCxGC-TOF/MS), which is suited for forensic investigation of complex matrices. In an examination of five plastic children’s toys, a total of 306 unique compounds were identified across all toys, including 102 Tox21 chemicals such as diethyl phthalate and bisphenol AF. As many as 114 and as few as 56 chemicals were identified in each toy. Across the five toys, a range of 0 to 40 unique peaks remain unidentified. Interestingly, bisphenol A (BPA) was identified in a children’s toy marked as “BPA free” demonstrating the need to measure the unintended presence of some chemicals in otherwise well-characterized products. In addition to characterizing more products, we are identifying unknown chemicals by broadening the library of retention times and spectra for likely suspect chemicals among the Tox21 chemical library. The qualitative and quantitative information developed from this project will be used to calculate and refine exposure estimates for the thousands of chemicals of chemicals in articles and consumer products. This abstract does not necessarily reflect U.S. EPA policy
URLs/Downloads:
DOI: Product Deformulation to Inform High-throughput Exposure Predictions (SOT)
SOT2016_WAMBAUGH_EXPOCAST_POSTER_V10_FINAL.PDF (PDF, NA pp, 2019.926 KB, about PDF)
WAMBAUGH SOT-2016-EXPOCASTPRODUCTS-ABSTRACT-092315.PDF (PDF, NA pp, 185.792 KB, about PDF)