You are here:
HEXACHLOROBENZENE (HCB) INDUCED HYPERPARATHYROIDISM AND OSTEOSCLEROSIS IN RATS
Citation:
Andrews, J., K. Courtney, AND W. Donaldson. HEXACHLOROBENZENE (HCB) INDUCED HYPERPARATHYROIDISM AND OSTEOSCLEROSIS IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/239 (NTIS PB90143041).
Description:
Hexachlorobenzene (HCB) exposure has been shown to alter the normal concentrations of parathyroid hormone and 1,25-dihydroxy vitamin D3 in rats and to result in osteoporosis in humans. xperiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism and to determine its effect on bone in rats. ischer 344 rats were dosed 5 days/wk for 5, 10 or 15 wks with 0, 0.1, 1.0, 10, or 25.0 mg HCB/kg body weight. ody weight was not affected by any of the exposure conditions. iver weight was significantly elevated above control values at the two higher dose levels at all three time periods. idney weight and kidney-to-body-weight ratio was significantly elevated at the highest dose level after 10 weeks and at the two higher dose levels after 15 weeks of exposure. erum alkaline phosphatase was significantly decreased at the two higher dose levels after both 10 and 15 weeks of exposure. ,25-dihydroxy vitamin D3 was measured in the 5 week exposure group only and was significantly elevated in the three higher dose levels. fter 5 and 15 weeks of exposure, parathyroid hormone concentration was significantly elevated at the two higher dose levels at both time periods. et femur density was significantly increase at the two higher dose levels of HCB after 10 weeks of exposure and the three higher dose levels after 15 weeks of exposure. ry femur density was also increased in the cases where wet femur density was increased. owever, femur weight was not affected at any dose level. he results from this study indicate that HCB induces