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Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort.
Citation:
Breitner, S., A. Schneider, R. Devlin, C. Ward-Caviness, D. Diaz-Sanchez, L. Neas, W. Cascio, A. Peters, E. Hauser, S. Shah, AND W. Kraus. Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort. ENVIRONMENTAL INTERNATIONAL. Pergamon Press Ltd., New York, NY, 97:76-84, (2016).
Impact/Purpose:
This study aimed to explore the influence of short-term exposures to PM2.5 and ozone on selected metabolites in a cohort of individuals who had undergone cardiac catheterization. We evaluated whether these associations are modified by participant or lifestyle characteristics. Since the population at hand is high risk, our findings may help to identify a particular subgroup that is especially susceptible to the health effects of air pollution.
Description:
RATIONALE: Exposure to ambient particulate matter (PM) and ozone has been associated with cardiovascular disease (CVD). However, the mechanisms linking PM and ozone exposure to CVD remain poorly understood .OBJECTIVE: This study explored associations between short-term exposures to PM with a diameter <2.5µm (PM2.5) and ozone with plasma metabolite concentrations.METHODS AND RESULTS : We used cross-sectional data from a cardiac catheterization cohort at Duke University , North Carolina (NC), USA, accumulated between 2001 and 2007. Amino acids, acylcarnitines, ketones and total non-esterified fatty acid plasma concentrations were determined in fasting samples . Daily concentrations of PM2.5 and ozone were obtained from a Bayesian space-time hierarchical model, matched to each patient's residential address.Ten metabolites were selected for the analysis based on quality criteria and cluster analysis. Associations between metabolites and PM2.5 or ozone were analyzed using linear regression models adjusting for long-term trend and seasonality, calendar effects, meteorological parameters, and participant characteristics. We found delayed associations between PM2.5 or ozone and changes in metabolite levels of the glycine-ornithine-arginine metabolic axis and incomplete fatty acid oxidation associated with mitochondrial dysfunction.The strongest association was seen for an increase of 8.1µg/m3 in PM2.5 with a lag of one day and decreased mean glycine concentrations (-2.5% [95% confidence interval: -3.8%; -1.2%]).CONCLUSIONS : Short-term exposures to ambient PM2.5 and ozone is associated with changes in plasma concentrations of metabolites in a cohort of cardiac catheterization patients. Our findings might help to understand the link between air pollution and cardiovascular disease.
