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Using the parallelogram approach to estimate human percutaneous bioavailability for novel & legacy brominated flame retardants
Citation:
Knudsen, G., M. Hughes, S. Hall, J. Sanders, AND L. Birnbaum. Using the parallelogram approach to estimate human percutaneous bioavailability for novel & legacy brominated flame retardants. Dioxin 2016, Florence, ITALY, August 28 - September 02, 2016.
Impact/Purpose:
We anticipate these data will be useful in estimating human exposure risk to brominated flame retardants, especially to small children who are exposed to higher levels of household dust. This is of particular importance because, coupled with their increased surface area to volume ratio and immature detoxification pathways, early-life exposure to endocrine disrupting chemicals like EH-TBB & BEH-TEBP enhances susceptibility to obesity, diabetes, cancer, and other chronic pathologies.
Description:
(This is an extended abstract. The following text was taken from the Discussion and Conclusion section.) Humans are frequently exposed to brominated flame retardants (BFRs), especially via dermal contact with contaminated dust. Human and rat skin data were integrated using a parallelogram method to predict human absorption of three novel BFRs, EH-TBB, BEH-TEBP, and DBDPE, and one conventional BFR (TBBPA) that are being used as alternatives to banned FRs. TBBPA & EH-TBB were well absorbed while BEH-TEBP percutaneous absorption was low. The apparently large bioavailability for DBDPE was largely dependent on retention in the skin. Skin contact with these BFRs may represent an important route of exposure, especially for small children. Good hygiene practices may aid in decreasing residence time on the skin, which in turn could limit bioavailability and systemic exposure.